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clomidClomid serves to be a very effective when it comes to treating women problems mainly ovulation and infertility. In fact the drug has been widely used and is still utilized in medical world for curing the issue of female infertility.  A Selective Estrogen Receptor Modulator, Clomid by design binds to the receptors thereby preventing estrogen from binding; in simplistic terms it takes estrogens place at this binding point and this can serve and bring about several benefits to the intended individual. While binding to the receptors Clomid also simultaneously increases the release of both Luteinizing and Follicle Stimulating Hormones (LH & FSH) by way of stimulation; as both LH and FSH are imperative to testosterone production, without testosterone declines, through this direct stimulation natural testosterone production is increased. For the performance enhancer this presents two distinct benefits, one for On-Cycle protection by the receptor binding and one for Post Cycle Therapy (PCT) in-terms of re-stimulating proper natural hormonal production. For the treatment of low testosterone we can also easily begin to see the purpose, as increased LH and FSH lend to the desired end.

It is often believed by many that Clomid actively reduces the amount of estrogen within the body or that it actively blocks it from existing in the first place; for this reason many refer to it as an anti-estrogen but this is somewhat inappropriate. Clomid does not inhibit estrogen production nor does it reduce the amount of estrogen in the body. Yes, there are medications that have this affect, most notably aromatase inhibitors, the most common being Arimidex and Letrozole. However, while Clomid does carry with it some similarities, especially revolving around HPTA its direct nature is unique in comparison to aromatase inhibitors.

For the anabolic androgenic steroid user there are three distinct benefits separated into two distinct categories; therapeutic testosterone replacement and performance enhancement. As we are aware many anabolic steroids convert into estrogen once present in the human body and never is this truer than with the advent and presence of exogenous testosterone. The cause of this estrogen conversion is largely brought on by what is commonly referred to as the aromatase process and it is this process that can lead to many of the most commonly known steroidal side-effects. Estrogen buildup is largely responsible for the brunt of anabolic steroid related side-effects and perhaps the most threatening for many is Gynecomastia or what is commonly known as Gyno or male breast enlargement. It is true, Clomid will do very little to reduce the total amount of estrogen in the body, in-fact it really wont do anything at all but it can prevent the existing estrogen from binding to the receptors of the pectoral region thereby preventing the onset of Gynecomastia. It is important to note, while this binding at the receptors can be very efficient it is limited in action; those who are extremely sensitive or who have a greater buildup of estrogen than Clomid can bind will find this SERM to be useless in-terms of side-effect prevention. For this individual only an active aromatase inhibitor will do; in the case of this individual we need a medication that not only inhibits estrogen from existing by conversion but one that actively reduces the total amount as well; this is where Arimidex and Letrozole really become invaluable.

While Clomid has a use for on-cycle steroid use it is perhaps during PCT that it really shines through and it is here most in the performance enhancing world will find it most beneficial and understanding this is relatively simple. When we supplement with anabolic androgenic steroids our natural testosterone production is suppressed; the degree varies depending on the steroids used and dosing and duration can also have an effect but regardless suppression will exist. Because natural testosterone suppression exists most will supplement with the testosterone steroid while on cycle; it is important to note, even the testosterone steroid actively suppresses natural testosterone production. As natural production is suppressed, while on cycle if exogenous testosterone is being used this is of very little concern; after all, with exogenous testosterone use we ensure we have the testosterone we need in our body and yes, you need testosterone as it is a hormone of absolute vital importance. Once the cycle is complete this is where some find they run into trouble; it is very common for gains from a cycle to be lost to the wind and for an individual to put on a little fat and just feel like a pile of garbage. Why does this happen, its simple, theyre not producing any or enough testosterone and no longer have any exogenous testosterone to meet this end. Through the use of Clomid, recall, it actively stimulates the release of natural testosterone we can see this problem remedied as it becomes a concern of distant memory past.

It is commonly understood, testosterone is produced in the testicles of men but many fail to understand this is not where production begins; yes, you need well-functioning testicles but in many ways this is the end of the testosterone assembly line. To produce testosterone in adequate amounts we may aptly say production begins at the pituitary; the pituitary must release LH and it must release an adequate amount; the amount of LH released greatly determines the amount of testosterone produced. Again, recall from above, Clomid greatly stimulates LH release, thereby stimulating total testosterone production and aiding in ensuring enough testosterone is in the body. For years, in-fact decades performance enhancers have supplemented with Clomid for PCT purposes in order to preserve gains made but while this is important it proves to be even more important in-terms of preserving overall health; remember, testosterone is essential, so essential we can aptly label it one of the most important hormones the human body will ever produce.

As Clomid so greatly stimulates natural testosterone production the benefit for the low testosterone patient is very easy to see; if you suffer from low testosterone you simply need to produce more and Clomid can provide a means by which your naturally produced levels can increase. For many men this is a welcomed medication to fill this role; simply take a pill once or twice a day and be done with it, problem solved but more times than not its simply not that simple. While Clomid can be beneficial and effective in low testosterone treatment more times than not it is not strong enough and direct testosterone therapy is needed; meaning, some sort of exogenous testosterone must be applied.

The Side-Effects of Clomid:
Anabolic steroids, SERMs, NSAID painkillers such as Aspirin, they all carry with them possible side-effects, some more so than others and individual sensitivity always plays a large, very large role; while simplistic it is no different than how some are lactose intolerant while others are not. Remember, possible side-effects simply mean maybe it can happen and in no way means it will. As it pertains to Clomid we have a relatively side-effect friendly medication in-fact most will experience no side-effects at all but of those that do the most common is blurred vision. No, blurred vision does not mean blind, it simply means blurred and it will return to normal once use is discontinued. Some individuals have also reported abdominal discomfort and even hot flashes but both are extremely rare, so rare less than 1% of all Clomid users will ever experience them to any degree. Some Clomid users have also reported acne, especially on their back or shoulders but this is largely due to the increase of the now higher natural testosterone production and generally clears very fast as the body adapts and becomes accustomed.

anadrolThis artificial anabolic steroid is medically recommended to provide relief to patients suffering with health complications such as anemia and osteoporosis. It is also recommended to people afflicted with failure of bone marrow and enhancement of red blood cell count. The steroid is also admired for stimulation of muscle growth in underdeveloped or malnourished patients and protecting joints under heavy loads or during intense workouts. In addition to that, Anadrol is also popular among sportsmen for possessing the strongest anabolic effects of all oral steroids. Belonging to the family of Dihydrotestosterone (DHT), Anadrol is free from all negative effects of steroids, when used as per instructions of a qualified medical practitioner. This steroid is best used in dosages of 1-5 mg per kilogram of body weight (on a daily basis) though some sportsmen make use of Anadrol in dosages of 1-2 mg per kilogram of body weight per day. Also known as Oxymetholone (A50 or A-bombs), Anadrol is one of the most commonly used anabolic steroids among budding as well as professional sportsmen. The fact that it has the ability to improve the production and urinary release of erythropoietin without leading to side effects is one of the biggest reasons behind its popularity.

By using Anadrol, sportsmen and others can expect dramatic improvements in the levels of muscle mass, protein synthesis, nitrogen retention, aggression, and body strength with just four to six weeks of use. Use of Anadrol is also related to promotion of lean muscle mass and stamina improvements. The steroid is commonly made a part of bulking steroid cycles, and is rarely used for cutting steroid cycles.

One of the most common Anadrol only cycle is all about using it in doses of 50 mg per day for the first week, 100 mg every day for the 2nd and 3rd weeks, 50 mg every day for the 4th and 5th weeks, and 25 mg every day for the 6th week. A popular anabolic steroid stack involving Anadrol is about 7 tablets of Anadrol every day (of 50 mg each) for 6 weeks, Dianabol 5 mg every day for 6 weeks, Proviron for weeks 3-5, and post cycle therapy with Nolvadex 10 mg every day for three weeks. Anadrol is commonly stacked by users, especially those into body building and strength athletics, with legal anabolic steroids and performance enhancing drugs like Boldenone, Nandrolone, and Testosterone during an anabolic steroid cycle of six to eight weeks.

The use of Nolvadex proves beneficial to Anadrol users towards the end of a steroid cycle as the antiestrogen has the potential of enhancing bio-availability of steroids used in the cycle and restore or improve production of natural hormones such as testosterone at the earliest. Use of Nolvadex also proves beneficial to minimize or eliminate estrogenic side effects such as bloating, acne, oily skin, and gynecomastia. Antiestrogens like Clomid or Arimidex may be made be a part of post cycle therapy (in place of Nolvadex) for an Anadrol only cycle or a cycle with Anadrol as one of the steroids.

The steroid is not usually recommended to girls and women, especially those who are pregnant and lactating. Anadrol is also not recommended to those suffering from breast, testicular, and prostate cancer and those having existing allergy to Anadrol or its ingredients. The abuse of Anadrol or use of low grade Anadrol or use of the steroid in absence or contravention to medical advice may lead to side effects such as nausea, diarrhea, queasiness, sleeplessness, and swelling. The abuse of Anadrol may even cause health troubles such as hepatitis and cirrhosis or hoarseness, growth of facial hair, acne, and changes in menstrual cycle. Anadrol abuse may even cause health complications such as persistent or frequent erections, bladder irritability, and decrease in seminal volume, or aggravation of acne.

It is highly recommended that Anadrol users undergo liver function tests at regular intervals due to the hypertoxicity associated with the use of 17-alpha-alkalyted androgen’s. Regular X-ray examinations at a gap of six months to examine bone age should be undertaken during treatment of prepubertal patients for ascertaining the rate of bone maturation and comprehensive effects on the epiphyseal centers of the androgenic anabolic steroid therapy. Individuals administered with high Anadrol dosages are best checked on a frequent basis for polycythemia and patients with anemia are to be examined for ascertaining the serum iron and iron-binding capacity. Medical practitioners may recommend Anadrol to women who have already been hormonized.

In case any side effect or abnormality is experienced after making use of this anabolic steroid, the usage should be discontinued on an immediate basis and advice of a qualified medical practitioner should be sought without delays. The dosages of Anadrol should not be increased or decreased without prior medical approval and the dosages should never be abused in hopes of quick results. Moreover, no two dosages of the steroid should be taken together even if the first one is missed accidentally or unknowingly.

Deca Durabolin has become one of the most widely used steroid compounds within the last thirty years due to it’s ability to provide large gains in muscle mass, relieve joint pain and actually help the immune system. Another benefit of Deca Durabolin for bodybuilding is that it doesn’t seem to have many side effects due to the fact that it won’t convert to estrogen in the system to the degree that many other steroids do.
deca
This is not to say that Deca doesn’t have its issues. For one thing, in order to be effective for bodybuilders, Deca needs to be taken for at least 12 weeks at a time. Deca must also be taken in conjunction with testosterone since the body’s natural production of testosterone will drop. Once a Deca cycle has run its course, testosterone should continue to be taken. Known side effects of taking Deca are acne and water retention.

“Deca” as Deca Durabolin is most often called, is extremely popular around the globe. It has gained a reputation for exhibiting some very favorable properties. Its chemical structure is very close to the chemical structure of testosterone, just lacking in a single carbon atom located at the 19th position, which has earned it the name “19-nortestosterone”. Due to this Deca provides a much milder androgenic effect than testosterone does. Deca is only somewhat androgenic, but occasionally a woman will experience the symptoms of virilization. When this is a concern it is recommended that the women take Nandrolone Durabolin instead, as it’s a shorter acting drug and therefore safer. It only stays active in the body for several days, which greatly reduces androgenic buildup when withdrawal is indicated.

When men take Deca Durabolin they need to be concerned about their level of testosterone, especially if taking in a cycle of long duration. To combat this it is necessary to use an ancillary drug at the end of the Deca cycle for bodybuilding. Clomid or Nolvadex are commonly used for this purpose since both are estrogen antagonists. Both these drugs are effective in stimulating the natural production of testosterone, although it may take awhile, maybe two weeks before the effects are apparent. As an extra precaution HCG injections may be helpful as this will act to quickly restore the testes’ normal ability to respond to the resumed natural release of gonadotropins. What’s interesting is that Nandrolone does not break down and transform into a stronger metabolite in androgen target tissues. This is one of the main problems with testosterone. Nandrolone does in fact undergo a reduction through the 5-alpha reductase enzyme that’s responsible for producing DHT from testosterone, but dihydronandrolone is produced in this case.
This is a weaker metabolite than Nandroloness, from which it is derived, and therefore much less likely to bring about negative androgenic side effects in the user. Very rarely will you see strong cases of acne or oily skin, excessive body or facial hair and/or hair loss. This doesn’t mean that androgenic activity doesn’t ever occur because, like with any steroid, it can happen. However when it happens with Nandrolone it is usually due to taking higher doses than recommended.
Deca Durabolin also demonstrates a lot less tendency for converting to estrogen. When you compare this with testosterone, you will see only about 20% as much conversion. This is due to the fact that although the liver does convert Nandrolone to Estradiol, when Nandrolone is injected into adipose tissue the conversion is far less likely. This means that side effects related to estrogen are a lot less of a concern with Nandrolone. Because of this an anti-estrogen drug is rarely needed and the likelihood of developing gynecomastia is only a concern for very sensitive bodybuilders.

List of Side Effects:
Water retention is not usually a concern with this drug either which means that mass gains for bodybuilders will be permanent and will not disappear after a few weeks. It does happen, but when it does it is more often than not a result of taking higher dosages. If you add Nolvadex and Proviron this should take care of the matter however.

Deca has very clearly demonstrated itself to be very safe when compared to other steroids. When everything, including side effects and results, is considered many believe that Deca is the best overall steroid for males. It is also interesting to note that there have been studies on HIV patients that have shown the effectives of Deca in safely adding lean body weight to patients as well as helping to strengthen the immune system of those with HIV. Notable as well is that Nandrolone seems to act as a progestin in the body’s system. Since progesterone is a c-19 steroid, when you remove this group of steroids, as with a 19-norprogesterone, the result is a hormone that binds more strongly with the corresponding receptors. Because the 19-noranabolic steroids including Trenbolone share this trait, they seem to have an affinity for binding with progesterone receptors too. This factor may cause some progestin-like reactions in the body and possibly intensify the associated side effects.

The side effects related to progesterone are in fact very similar to the side effects of estrogen, including inhibiting the production of testosterone, increased rate of storing fat and the possibility of developing gynecomastia. It is commonly believed that the progestin-like activity of Deca does contribute to the suppression of the production of testosterone, which can be considerable even though there is a diminished tendency of Deca converting to estrogen. This is what makes it so well suited to use Deca Durabolin for bodybuilding.

winstrolWinstrol Oral is a very popular oral or injectable anabolic-androgenic steroid. It ranks up there with Deca and Dianabol as the most widely used and abused drug by competitive athletes.

Stanozolol is commonly referred to as Winny (Winstrol). Winstrol comes in two forms as mentioned above – both oral and injectable. The injections are the same methylated compound as the oral form of the drug. However, due to this feature, it cannot be esterified for time release. Winstrol Oral has a short active life of around eight hours. Winstrol Oral counteracts estrogenic side effects such as gyno and water retention – another quality which makes it attractive to the athlete seeking lean mass gains. Winstrol Oral is a 5-alpha reduced substrate. 5-alpha reduction breaks the double bond between positions 4 and 5, which is what is required for aromatase to convert to estrogen. Aromatase is the primary enzyme used for the manufacturing of estrogen within the male body. For avoiding gyno, Winstrol Oral is well suited.

Since Winstrol is not capable of converting into estrogen, anti-estrogen ancillary drugs such as Nolvadex or Clomid are not necessary when using this steroid. Gyno will not be a concern for even the most sensitive individuals when using this steroid. Winstrol is excellent for lean gains since water retention is reduced when using this steroid. This is due to the fact that estrogen is the cause of water retention. It is excellent to use among athletes who are seeking for a combination of both strength and speed.

Winstrol Oral, like Dianabol, should not be used for extended periods of time since it is a 17-alpha-alkylated substance, using it for much longer than 4-6 weeks is not advisable. Some athletes have been known to use it for eight weeks or even longer, but elevated liver values are a possibility if this is the case. For the sake of safety, such a long length of use is not recommended. 4-6 weeks will give the user good results and will add a boost to his or her steroid cycle, especially if stacked with a longer acting injectable ester. The reason for quick results with Winstrol Oral is due to its short active life and combined with a greater frequency of injection or oral consumption, results are fairly quick. Dianabol is also used for this purpose.

When using Winstrol Oral, many of the usual side effects are rare. These include acne, water retention, high blood pressure, and aromatization leading to gyno. Winstrol does not convert to DHT and it results in very minimal suppression of the HPTA. However, since it is a 17-alpha-alkylated substrate, liver toxicity is a concern in high doses of Winstrol or when used for extended periods of time. However, it is slightly less hepatoxic than most other 17-AA steroids. Elevation in liver values is nevertheless common with Winstrol if used for extended periods of time or at high doses.

The normal dosage for men is between 30-70 mg per day for the tablets and 25-50 mg per day for the injectable version of Winstrol. Winstrol Oral is often combined with other steroids depending on what the personal goals of the athlete are. To gain muscle mass (bulking) Winstrol is best combined with a stronger androgen such as Testosterone. This will give the cycle a good anabolic effect while minimizing estrogenic activity. This results in excellent increases in lean muscle mass, as opposed to the more common bulking cycle which greatly increases muscle mass while also increasing water retention and some gains in fat. To lose fat (cutting), Winstrol Oral is best combined with a non-aromatizing androgen such as Trenbolone or Halotestin. This combination can create a strongly defined, hard look. This is a very attractive look sought out by many bodybuilders. Woment should take around 5-10 mg daily for the recommended length of time of 4-6 weeks.

When we supplement with anabolic androgenic steroids, our natural hormone levels are altered. Most anabolic steroids suppress our natural testosterone production to one degree or another, and if we’re not careful our estrogen and progesterone levels can increase beyond a healthy range. Of course, estrogen and progesterone can both be controlled while on cycle with proper supplementation practices, but the testosterone suppression will remain. Then we reach the point where our cycle has come to an end; we have discontinued the use of all anabolic steroids, and as a result something must be done. When we discontinue our steroid use, our testosterone levels are still in a suppressed state, and it’s often recommended you stimulate natural production and let your body normalize. While testosterone stimulation is the primary purpose, the normalization factor of a post cycle therapy plan is greatly important. Of course, as eluded to early on, sometimes implementing a PCT isn’t the best idea, and will delve into that shortly.
pct
The primary purpose of post cycle therapy is to stimulate your natural production of testosterone and shorten or enhance the total recovery process. Understand this here and now; there is no post cycle therapy plan on earth that can return your natural testosterone levels back to where they were prior to anabolic steroid use. Further, if you supplemented with anabolic steroids improperly and caused severe damage to your HPTA there’s no PCT plan that will help you. In any case, assuming your cycle was of a responsible nature, a post cycle therapy phase will by design stimulate your pituitary to release more Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) which will in-turn stimulate the testicles to produce more testosterone. Without such a PCT plan, it could easily take a year or more for your natural levels to recover, and this is not only stressful to the body, it can lead to numerous low testosterone symptoms; not to mention it is extremely unhealthy. Conversely, when you implement your post cycle therapy treatment, you will significantly cut down your total recovery time, but there’s something more important. While your natural levels will not be fully recovered, you will have ensured your body has enough testosterone for proper health and function while your levels continue to naturally rise. Sure, you can forgo such a plan if you like, but you’ll only be causing more stress to your body over the long haul, and limiting stress is in part how we define successful performance enhancement; after all, if you’re stressing your body post cycle, this means your steroid use has not be as successful as it could have been.

It should go without saying; the time to implement  post cycle therapy is when all anabolic steroid use has come to an end; this is a given; however, it’s not quite that black and white. If you’re going to be off-cycle for only a short period of time, a PCT plan can be counterproductive and cause even more stress to the body. Remember what we said above; limiting stress is extremely important. If you’re only going to be off-cycle for a short period of time, there’s no reason to stimulate your natural production when you’re going to immediately shut it down again; talk about a shock the body does not appreciate. For this reason, a post cycle therapy period should only be implemented when we’re going to be off-cycle for an extended period of time; meaning, no anabolic androgenic steroids will be present in our system. Of course, the next order of business is to define an extended period of time, and twelve weeks is a good place to start. If you’re going to be off-cycle less than 12 weeks, while you will lose some of your gains they will come back shortly once you go back on-cycle. Conversely, if you’re going to be off-cycle longer than 12 weeks, it’s time for a PCT plan for the reasons discussed above. It must be noted; this time frame of “off-cycle” does not include the PCT period; off means off everything. Now that you understand what a post cycle therapy plan is and when and why you should implement it, you need to understand how to implement it and the options you have. How you cycled your anabolic steroids will play a role, but regardless of your steroid use your PCT plan will always include a Selective Estrogen Receptor Modulator (SERM), and Tamoxifen Citrate (Nolvadex) and Clomiphene Citrate (Clomid) will always be your best options. Recall what we discussed above in-regards to LH and FSH stimulation; it will be the SERM you use that causes such an action. It really doesn’t matter which SERM you choose, both can get the job done equally as well; simply pick one.

Beyond SERM use, which is essential, we have a few additional options; primarily Human Chorionic Gonadotropin (hCG). hCG is an extremely powerful peptide hormone that can be used to prime the body for the SERM therapy to come due to its LH mimicking effect. Of course, hCG abuse can be very dangerous as it is potentially damaging to your HPTA if you use too much or for too long; if you do, your body may become dependent on the mimicked LH. Beyond hcg, another option can be Human Growth Hormone (HGH) as this will greatly protect your gains made while on-cycle as well as limit body-fat gain that can easily occur post steroid use. While HGH can be useful, you will only be using it if you were using it on-cycle; HGH is something that must be used for extended periods of time, and there’s no point in adding it into a PCT plan that’s only going to last a few weeks.
If your cycle ends with even one large ester anabolic steroid, if you’re only using a SERM you will begin SERM therapy approximately 14-18 days after your last injection. If you’re going to use hCG, you will begin hCG therapy 10 days after your last injection, complete it for 10 days and then begin SERM therapy. As for small esters, if your cycle ends with all small ester based anabolic steroids and you’re only using a SERM you will begin SERM therapy approximately 3 days after your last injection. Conversely, if you’re using hCG, you will begin hCG therapy 3 days after your last injection, complete it for 10 days and then begin SERM therapy. While Nolvadex and Clomid can work equally as well, they will only work equally as well if they are dosed properly. This is where many fail when they use Clomid as Nolvadex is much stronger on a per milligram basis. For example, with 40mg of Nolvadex, for Clomid to match it you need 150mg. As for hCG dosing, 500iu to 1,000iu per day every day for 10 straight days is your plan and implemented precisely as discussed above. Once the hCG therapy is complete, you will start your Nolvadex therapy at 40mg per day or Clomid at 150mg per day; whichever you choose, you will continue it for two weeks. Once the two weeks is complete, you will complete two more weeks this time with a Nolvadex dosing at 20mg per day or a Clomid dosing at 100mg per day. No, you’re not done yet, you will complete one more week at 10mg per day for Nolvadex or 50mg per day with Clomid and add in an additional week at the same dose if you feel it is necessary.

Anabolic androgenic steroids (also known as AAS and steroids) are chemically modified versions or derivatives of the naturally-occurring male sex hormone, testosterone, which is produced naturally in both men and women. In other words, steroids refer to drugs (excluding estrogens, progestins, and corticosteroids) or hormonal substance, which are chemically related to testosterone that promotes muscle growth.

Today, there are more than hundreds of varieties of these drugs, but only a few have been approved for human or veterinary use and a prescription is required to purchase these drugs for medicinal purposes.

cernosgelWhat Is Testosterone:
Testosterone is produced particularly by the male testicles and other organs and tissues in females. The circulating blood level of this hormone in females is 10 percent that of their male counterparts. The naturally-occurring male sex hormone circulates throughout the body and interacts with specific receptors on the cells to initiate balanced development of the male sexual characteristics like hair, genitalia, and male features. Testosterone is also responsible for the proper functioning of many other organs and tissues in the body. All anabolic steroids, because of their chemical similarity to testosterone, have the potential of interacting with cell receptors and produce effects in all organs and tissues, including muscles, bone, bone marrow, blood vessels, the brain, heart, liver, skin, skin, hair, the genitals, and the reproductive organs.

There are two types of anabolic androgenic steroids:

Exogenous steroids: These are synthetic versions of the male primary sex hormone, Testosterone, and common examples include Nandrolone and Danazol. These are substances that are not capable of being produced by the body naturally.

Endogenous steroids: They refer to naturally occurring substances involved in the metabolic pathways of testosterone. These are substances capable of being produced by the body naturally.

Anabolic steroids have been used and abused for many decades by those into sports and fitness who are trying to augment their anabolic and androgenic potential.

Anabolic steroids were first made available in the 1930s, when a team of scientists created a synthetic form of testosterone for men who were unable to produce enough of the hormone for balanced and normal growth, development, and sexual functioning.

Why Are Steroids Used:

The use of anabolic steroids is common among bodybuilders, athletes, and fitness “buffs” who claim that these drugs give them a competitive advantage, promote the sense of well being and invincibility, and improve their physical performance.
There may be peer pressure to use these drugs in some individual or team sports due to the “fear” or “assumption” that normal training will not be enough to succeed.
Many others start using anabolic steroids with the perception that other athletes are using them and gaining an unfair advantage.
Anabolic steroid use may also be prompted by muscle dysmorphia or abnormal perception of the body.

Steroids are used medically to treat health conditions like hypogonadism (defect of function of the testes or ovaries), severe cases of osteoporosis, COPD (Chronic Obstructive Pulmonary Disease), some forms of anemia, Klinefelter’s syndrome (Sometimes known as XXY syndrome), Angioneurotic edema (swelling in the deep layers of the skin), delayed puberty, and Human immunodeficiency virus (HIV) wasting syndrome.

These extremely potent drugs are medically used to treat anemia (low red blood cell count), control breast cancer in women, improve weight loss due to severe illness, and treat hereditary angioedema that leads to swelling of the face, arms, legs, throat, windpipe, bowels, or sexual organs. Steroids may also be recommended in the treatment of severe burns, short stature, and prolonged catabolic state secondary to the long-term use of corticosteroids.

Androgel (transdermal testosterone) is a topical gel that is applied to the skin, in order to help men with low testosterone (under 300ng/dl) get their T levels within range. It is the basis of the majority testosterone replacement therapy (TRT) prescriptions in the USA.

Interestingly, some athletes will use androgel to boost their testosterone levels without having to use needles. However, the results are somewhat questionable for athletic performance due to low testosterone doses.

Low testosterone symptoms include:

Loss of libido
Erectile dysfunction (ED)
Loss of muscle mass and strength
Increased body fat
Lethargy and insomnia
Weak immune system
Androgel (testosterone gel) is not injected or taken orally. Instead, it is a synthetic testosterone mixed into a gel that is applied to the skin daily, and is absorbed through the skin into the bloodstream. This allows for 24 hour delivery into the body. There are two strengths 1% and 1.62%. The method of deliver is via a pump flask or through single dose packets. The 1% is applied onto the upper arms/shoulders/abs, and the 1.62% gel is only applied to upper arms/shoulders. Best time to use is after morning shower, apply and let dry, then put on clothes. After application, you should avoid showering or swimming for 2-4 hours.
Androgel (testosterone gel) is suppressive, so if someone plans on coming off they should run a post cycle therapy (PCT) to help avoid a drop in sex drive, muscle mass, strength, and increase in body fat. Side effects, mostly seen in older men are blood clots, blood pressure increase/heart strain, liver issues, increased RBC, and headache are common. Since testosterone does aromatize into estrogen, androgel has possible estrogenic side effects. If the user is sensitive to estrogenic sides, he can have issues with breast soreness (gynecomastia), water retention, and sides related to heart strain. It is recommended an aromatase inhibitor (AI), such as Aromasin or Arimidex, be on hand or used lightly. Women should not use androgel, and care should be taken to avoid direct skin contact with their spouses who have applied it.

testosterone_cypionateThe androgen hormone testosterone plays an important role in physical and sexual development. When testosterone levels are normal, males pass through puberty and into adulthood with the capacity for normal sexual functioning and fertility. If testosterone levels are too low, men may lose muscle mass, develop medical conditions such as anemia and bone thinning, and experience sexual dysfunction or infertility. Testosterone replacements products like testosterone cypionate can help regulate blood levels of the hormone.

Testosterone Cypionate comes in a clear, oil-based solution that’s injected deep into the gluteal muscles in a doctor’s office or at home. The physician will prescribe the amount of the drug to be administered, as well as the frequency of injections. Since the oil-based product is absorbed slowly into the body, most men need injections every two to four weeks.

The U.S. Food and Drug Administration has approved Testosterone Cypionate for men with testicular conditions that limit their ability to produce testosterone. These include birth defects, trauma and infection. It’s also indicated for disorders of the pituitary gland or hypothalamus that interfere with the testosterone production cycle, as well as damage from cancer, radiation or trauma.

Testosterone Enanthate and Cypionate are almost identical with the only difference being an additional carbon in the ester chain for Cypionate. Distinguishing between them is almost impossible and are therefore considered identical in terms of both effect and results. In reality, all other variables being equal, Enanthate is a slightly better value product due simply to the reduced ester weight. This accounts for 28mg of every 100mg of Testosterone Enanthate, in contrast to 30mg per 100mg for Cypionate. Although we’re splitting hairs here, the difference only amounting to 20mg per week in a 1gram per week cycle, it is nevertheless worth noting.

These longer estered testosterones require infrequent injection and are therefore perfectly suited to longer, typically mass cycles, where levels of steroids used tend to be higher. In contrast to Propionate, these testosterones are manufactured with a much higher mg/ml ratio without any pain issues for the user. 200-250mg/ml are typical, and makes higher dosed cycles a much easier prospect in terms of reduced oil volume. Indeed, some underground manufacturers have taken this to the extreme, with some versions boasting concentrations of 400mg/ml though this practice is considered unnecessary and such a preparation is likely to cause substantial injection soreness.

When using either Enanthate of Cypionate, a weekly dosing regime is perfectly adequate, though splitting twice is usually preferred as steroid concentration levels drop significantly around day four, and by doing so will ensure better stabilization. As you would expect from any variation of testosterone, mass and strength gains are very impressive, helping solidify testosterone’s dominance in the typical steroid user’s arsenal of available drugs. Examples of commonly seen cycles including these esters:

Novice mass cycle:
Testosterone Enanthate/Cypionate 1000mg week 1
Testosterone Enanthate/Cypionate 500mg pw, weeks 2-10

Advanced mass cycle:
Testosterone Enanthate/Cypionate 750mg-1250mg pw, weeks 1-12
Deca 600mg-800mg pw, weeks 1-10
Dianabol 40mg-50mg ed, weeks 1-4
Testosterone Propionate 100mg-150mg ed, weeks 12-15
Trenbolone Acetate 100mg-150mg ed, weeks 10-15

The final injectable testosterone option is actually a blend of esters, all contained in the same preparation. The most common of these testosterone blends include Sustanon and Omnadren. For example, Sustanon 250 contains the following in each 1ml ampoule:
– 30mg Testosterone Propionate
– 60mg Testosterone Phenylpropionate
– 60mg Testosterone Isocaproate
– 100mg Testosterone Decanoate

This type of steroid is often medically given to patients who opt for injectable testosterone therapy to treat their hypogonadism. It is favoured within the medical community for this purpose due to the fact that the blend of esters facilitates a much more uniform release and metabolism of the testosterone which in turn negates the need for frequent injections. This feature is apparent from the fact that some patients receive their injections as infrequently as fortnightly. Clearly, this form of testosterone is highly valued in the bodybuilding community, particularly by users who wish to limit injections and inject on a weekly basis.

It is thought by some that by avoiding a frequent administration schedule (such as every second day), a user will in some way ‘waste’ the benefit of the short prop and Phenylprop esters. How they arrive at this conclusion is anyone’s guess! The short esters are metabolised and utilised by the body regardless of the frequency of administration and to suggest that they somehow disappear into thin air is ludicrous. The nature of the ester blend is designed in such as way that the average rate of ester release is relatively uniform, not too dissimilar in essence to that of a single ester of Enanthate or Cypionate. In view of this, the use of Sustanon/Omnadren is interchangeable with Enanthate/Cypionate when constructing cycles.

Novice users will often ask which of the long esterified testosterones is the best. The short answer is that they are as good as each other, the only real differences occurring due to poor manufacturing processes by certain labs which may affect the actual amount of steroid contained resulting in an under/overdosed product. Other factors that may give a user the perception that one type is better might have been a better diet or training routine which may have led to a better result than previously experienced from another type of ester.

Possible Side Effects:
It will be of no surprise that steroids that can potentially lead to substantial results tend to have a greater risk of associated side effects, and in this regard testosterone is no different. Being both a considerable anabolic and androgenic hormone, the user should take necessary precautions when using testosterone to limit potential problems that may arise. Due to its profound effects on the hypothalamic pituitary testicular axis (HPTA) and subsequent suppression of endogenous testosterone production, the need for an adequate post cycle therapy (PCT) is paramount.

Testosterone interacts readily with the enzyme aromatase, which results in estrogen conversion. High circulatory levels of estrogen can lead to a number of issues including gynecomastia (the formation of male breast tissue, often referred to in slang terms as ‘gyno’ or ‘bitch tits’), water retention and fat deposition. It is clear that some users are much more sensitive to the effects of increased estrogen levels than others, and may notice typical early signs of the condition even from using a very modest dose of testosterone such as 500mg weekly. The user should recognise these early warning signs which can be just one or a culmination of: swollen, puffy, painful, lumpy, itchy or tender nipples. Should any of these symptoms become apparent, it would be prudent to control both existing circulating estrogen and the level of future estrogen conversion. This is achieved through the use of a Selective Estrogen Receptor Modulator (SERM) such as Tamoxifen (brand name Nolvadex) which, being a weak estrogen in itself will compete and occupy the breast tissue estrogen receptor rendering much of the troublesome circulating estrogen inert, and by the use of an anti-estrogen drug such as Proviron or Arimidex. These assist by binding and therefore blocking the effects of the enzyme responsible for estrogen conversion, thereby reducing actual circulating estrogen levels.

Testosterone Enanthate is one of the many esterified variants of Testosterone available. It is an injectable compound with a slow rate of release due to the larger Enanthate ester attached to the Testosterone molecule. This augments the release rate and half-life of Testosterone to that of a slower release. The majority of Testosterone products that have been designed are single products that contain a single esterified form, as opposed to Testosterone products which consist of a blend of several different esterified variants in the liquid (such as Sustanon 250, for example). Testosterone that is un-esterified holds a very short half-life, making its use very inconvenient and impractical (Testosterone suspension is one such Testosterone product that consists of pure un-esterified Testosterone, and does not have an ester bonded to its structure). The Enanthate ester expands Testosterone’s half-life to that of 10 days, and blood plasma levels of the hormone remain elevated for a total period of approximately 2 – 3 weeks. Testosterone itself is considered the most natural and safest anabolic steroid any individual can use, and it is easily the most versatile and flexible anabolic steroid in terms of how it can be utilized in cycles and for different purposes and goals.

testosterone_enanthateThe Enanthate variant of Testosterone had first been described in the early 1950s when it had landed on the market and experienced increasingly extensive use shortly thereafter. This was the very first injectable Testosterone ester preparation that provided slower release rates. Prior to the development of Testosterone Enanthate, the most widely utilized forms were either un-esterified Testosterone (Testosterone suspension) or the faster acting Testosterone Propionate, which holds a half-life of approximately 4.5 days, necessitating more frequent injections which can be inconvenient for many. As such, Testosterone Enanthate promptly replaced Testosterone Propionate as the Testosterone of choice by the medical establishment in the West, as well as athletes and bodybuilders utilizing it for performance and physique enhancement. In the United States, Delatestryl manufactured by Squibb was the very first Testosterone Enanthate product to be marketed, and it is still manufactured and marketed today only under different pharmaceutical manufacturers that have purchased the rights to market that name brand. Most recently 2005, for example, Indevus was the latest pharmaceutical company to manufacture and market the drug. Internationally (outside of North America, mostly) the brand name for Testosterone Enanthate is known as Testoviron, which unlike Delatestryl, has been manufactured by Schering ever since its original inception well over 50 years ago. Ultimately it is the Testoviron brand name that is the most popular and widely utilized Testosterone Enanthate product in the world.

Testosterone is the king of all mass builders and for this purpose is also fairly cost effective. It works well either alone or stacked to create a great bulking cycle. It has a high risk of side effects due to its conversion to DHT and has the potential to form estrogen, causing gynecomastia. These characteristics also cause it to have such excellent mass building tendencies. Due to some other side effects, such as water retention, it may not be the best used alone for lean mass gains, but with bulking comes the addition of a lot of muscle as well as some gains in fat and water weight. This is typical and a natural part of the enhanced bodybuilder’s bulking regiment.

Testosterone Enanthate is a long lasting single ester steroid. It is 7 carbons in length. What this means, is that more of the weight of the steroid is testosterone as opposed to ester weight. When taking a quantity of an esterified steroid, the total weight is a combination of both the ester weight and the steroid. That said, longer esters such as Cypionate have more ester weight (due to it’s 8 carbon length), and less overall steroid weight. For this reason, Enanthate would be preferred over Cypionate. Sustanon has even more steroid weight.

500 mg of Enanthate has more free based testosterone than 500 mg of Cypionate and 500 mg of Sustanon has more than either. However, due to the irregular release of Sustanon and the need to inject more frequently to take full advantage of the propionate and phenylpropionate esters and thereby make full release of the steroid itself, either Enanthate or cypionate will be better choices for the first time user, who will likely want to maintain stable blood levels of the steroid while minimizing injection frequency.

A long acting testosterone ester will be very helpful for your bulking needs and Enanthate is a product which is more simple than some of the other steroids out there. Not to say it is without its share of complications, but it’s a good choice, especially for those new to enhanced bodybuilding. Discontinuing the product is not an option in case side effects occur, because it will continue to aggravate these side effects over extended periods of time due to the long length of action of this steroid (3-4 weeks). Ancillary drugs such as Nolvadex, Proviron, Clomid and HCG may help, both during cycle and post cycle to help restore natural testosterone production. Testosterone Enanthate does aromatize slightly more than Sustanon, but when using either drug, one should be familiar with anti-estrogen’s such as Nolvadex or Clomid and use one of them when symptoms of gyno occur.

Those who have prostate problems or those who are sensitive to gyno (for example, those who developed a case of gyno during puberty), and those who are sensitive to female pattern fat deposits will want to ensure anti-estrogens are on hand during cycle in case gyno related side effects arise. As a general rule of thumb, you will always want to keep nolvadex on hand – but obviously, it is even more important if the risks of these side effects are higher than normal (depending on the user and his or her genetic predisposition).

Like any other testosterone, Enanthate suppressed HPTA function. Clomid or Nolvadex are important to have post cycle to stimulate normal testosterone function within a reasonable amount of time. You may also want to use HCG during your cycle, but this is matter of personal preference, as many feel they will be able to recover post cycle and don’t feel the benefit of HCG is worth the cost. Normalization of natural functions which were suppressed during cycle and testosterone production usually occur without the use of HCG, but at a slower rate than if it was used. Like anything in life, there is no guarantee of full recovery, but it would be a rare case if it did not happen.

Weekly totals of 250-1000mg weekly are frequently used, and sometimes more for the highly advanced athlete. Due to the relatively long half life of Enanthate (4-5 days), injections are usually administered twice per week. This will allow stable blood levels to be maintained. When the level of steroid tapers down, a new injection is made, keeping everything fairly level. This is unlike Sustanon, which requires more frequent injections for the same effect. For a first cycle, 500mg alone of Testosterone Enanthate, shot two times weekly (Monday and Thursday for example), for 10 weeks along with standard post cycle therapy would be very sufficient for good gains.

gp_nolvaNolvadex is the name of the drug whose scientific name is tamoxifen citrate. Nolvadex is not a steroid – it is a potent anti-estrogen used as an ancillary drug during cycle when symptoms of gyno occur. It can also be used post cycle to restore natural testosterone production. Symptoms of gyno can occur when using a cycle which contains drugs which aromatize, including (but not limited to) testosterones such as Enanthate, Cypionate and Suspension. The drug is an estrogen agonist / antagonist, which binds to estrogen receptors in different tissues. Whether Nolvadex acts as an estrogen agonist or antagonist depends on which type of tissue it is working in. When the tamoxifen molecule binds to the receptors, estrogen is blocked and cannot result in any type of action – therefore an anti-estrogen effect is exhibited. Nolvadex is used clinically in the treatment of breast cancer since many forms of breast cancer are responsive to the action of estrogen. Nolvadex (GP Nolva)  blocks its actions and works as an effective treatment. Aside from direct treatment of breast cancer, it is used as a preventative measure for those with a genetic predisposition for breast cancer. While Nolvadex is likely the most popular on-cycle anti-estrogen due to its affordable price, more potent remedies are avaialable such as Arimidex, Femara and Aromasin. These ancillary drugs prevent estrogen from being manufactured in the first place and make gyno related side effects virtually nonexistent.

There is an enzyme in the male body known as aromoatase which is capable of altering testosterone so that it forms Estradiol – an estrogen derivative. Estrogen is structurally similar to testosterone and it is present in the male body, but to a much smaller extent than testosterone. Since aromatase can aromatize many anabolic-androgenic steroids, increased levels of estrogen can be a concern for the on-cycle bodybuilder. These levels can cause side effects, the main one being gyno (the development of female breast tissue in men). Symptoms that gyno is developing are itchy nipples, swelling or a small lump under the nipple which is normally painful to the touch. If Nolvadex (GP Nolva) is not on hand during cycle and this lump is left to develop, it can increase in size and may become impossible to get rid of in any method short of surgery. The surgery required for gyno is a simple procedure, but if this can be prevented in some way, most athletes would be willing to make the choices required to do so. High levels of estrogen also lead to an increased level of water retained in the body. The obvious result here is a loss in overall muscular definition – or that “bloated” look. This look is caused by the retention of subcutaneous fluid which will make the athlete look more smooth. Normally this is not a problem for the athlete bulking up, and preventative measures are not an important concern. As estrogen levels rise in the body, fat storage may also be increased. Estrogen is the main reason why women have a higher percentage of body fat compared to men. It is always a smart idea to have all ancillary drugs on hand, including anti-estrogenic drugs such as Nolvadex (GP Nolva), before commencing a cycle. For it symptoms occur during cycle, you may find that you are unable to obtain such drugs and from there, complications can arise.

Nolvadex (GP Nolva) shows potential to increase production of follicle stimulating hormone (FSH) and lutenizing hormone (LH) in the male body which are both important to the enhanced athlete. This is the result of blocking the negative feedback inhibition caused by estrogen at the hypothalamus and pituitary. As a result, the hormones mentioned are released. Both Clomid and cyclofenil also have this function. Nolvadex is also able to have an impact on an individual’s level of serum testosterone. This is important for post cycle therapy when this testosterone stimulating effect is most beneficial. Nolvadex (GP Nolva) can help restore hormonal balance post cycle, which is also very important to the athlete.

Either Nolvadex or Clomid can be used on-cycle as anti-estrogens and post-cycle to help normalize testosterone production quickly. HCG can provide an excessive level of stimulation to the testes, which has the ability to shock them out of a long state of inactivity. Generally HCG is not necessary in small cycles where dosages are kept low. However, it will help normalize things faster than if it is not used, so many choose to run it on-cycle for this added benefit.

A standard dosage of Nolvadex on cycle as an anti-estrogen would be 10-30mg a day. The amount used would depend on what effect the user would like to elicit. More would clearly elicit a stronger effect, but users should determine how much they will require by starting at lower dosages and working their way up, so as not to use more than they require for the desired effect. For those steroid users who are using highly aromatizing substances (such as testosterone suspension), or those who have a sensitivity to estrogen, using Nolvadex (GP Nolva) during cycle will probably be a smart idea to start early in the cycle.

Nolvadex (GP Nolva) is specifically a non-steroidal SERM belonging to the triphenylethylene family of compounds that exhibits both Estrogen agonist and Estrogen antagonistic effects on the body. This means that although Nolvadex might block the effect of Estrogen at the cellular level in certain tissues, it can enhance Estrogenic effects in other areas of the body. These can be positive effects as well as negative effects. GP Nolva exhibits Estrogenic effects in the liver, for example, which for all intents and purposes is a positive effect, as its effects here result in a positive change in cholesterol profiles (something desired by many). The area of concern with Nolvadex is particularly in breast tissue, where it serves to act as an anti-Estrogen in this area (and a very strong one at that). This is where it is utilized in medicine, as a first-line treatment in Estrogen-responsive female breast cancer patients. It is even utilized in females that do not possess breast cancer, but are known as being in a high risk category (due to hereditary genetics or otherwise) as a preventative measure. It is through its medical application that one can easily see how such a compound would easily attract the anabolic steroid using bodybuilding and athletic community, as one of the more prominent concerns among anabolic steroid users is that of the Estrogenic effects caused by the use of aromatizable androgens (such as Testosterone, Dianabol, Boldenone, etc.), mores specifically: gynecomastia (the development of breast tissue). If gynecomastia is left unchecked, it can develop and grow beyond a reversible point whereby the only option for removal is that of surgery.

Nolvadex (GP Nolva) possesses other very desirable effect, such as its ability to increase circulating levels of endogenous gonadotropins Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), and through this, increasing the endogenous production of Testosterone. This is a perfect example of the mixed Estrogen antagonistic and agonistic properties of Nolvadex, where it works to block the ability for Estrogen to bind to receptors at the hypothalamus. This results in the manipulation of the negative feedback loop of the HPTA (Hypothalamic Pituitary Testicular Axis), and results in the increased output of gonadotropins (the hormones that signal the testes to begin or increase the output of Testosterone production). It is for this reason that Nolvadex is considered an absolutely essential component of a PCT (Post Cycle Therapy) program during the weeks following anabolic steroid use in order to restore the function of endogenous Testosterone production.

Nolvadex Post Cycle Doses:
For a good Nolvadex (GP Nolva) post cycle plan very few will ever need more than 40mg per day and most will find that ending with a lower dose of 20mg per day to be just about perfect. For the healthy adult male a good Nolvadex post cycle plan will run for approximately 4-6 weeks in total duration; 4 weeks should be the standard with 1-2 additional weeks being added if necessary. In most cases the additional weeks will only be needed if the anabolic steroid cycle was strong, was extended and of a high suppressive nature. A solid Nolvadex (GP Nolva) post cycle plan for most any man to follow would look something like this:

Basic Plan:
Week 1: 40mg every day
Week 2: 40mg every day
Week 3: 20mg every day
Week 4: 20mg every day

Extended Plan:
Week 1: 40mg every day
Week 2: 40mg every day
Week 3: 40mg every day
Week 4: 20mg every day
Week 5: 20mg every day
Week 6: 20mg every day

hexarelinHexarelin is another hexapeptide like GHRP-6.  Unlink the other GHRP’s out there, Hexarelin is the dark horse, the black sheep, the underdog not usually mentioned and often over looked for certain qualities.  This grossly underestimated peptide shouldn’t be pushed to the side, but rather examined to understand its benefits and usability for bodybuilders and athletes alike.
The structure of the amino acid is that of a hexapeptide known to help promote the release of growth hormone (GH).  The mechanism of action is not yet fully understood by scientists.  However, what we know is that Hexarelin has the ability to act both on the pituitary gland and the hypothalamus.  It is known to give the largest release of GH than any other GHRP. Like other peptides, Hexarelin has the ability to help promote more production of natural growth hormone, and it will not shut down the production of the body’s ability to produce GH.

Interestingly, the most amazing finding with Hexarelin was its ability to act on cardiac receptors separate from the GH releasing properties. The peptide can directly aid in cardio protective left ventricular pressure issues, as well as, help healing scar tissue on the heart.  Studies on lean and obese lab rats concluded that while lean rats were able to take advantage of the GH plasma increase better than the obese rats (the healthier the rat the more Hexarelin effectively produced and utilized GH), obese rats did not see the same advantage.  Separate from the studies that monitored GH, both lean and obese rats both received all of the cardio protective properties of Hexarelin.

When Hexarelin is given as a subcutaneous injection, it activates the pituitary via a pulse, just like GHRP-6, and helps circulate growth hormone in the body.  Unlike GHRP-6, it does not induce any hunger side effects.  Hexarelin has the ability to not only raise the level of GH in the body but to also suppress somatostatin, which is the main culprit that inhibits GH from being released.  This means that there will be more GH in abundance.  In addition, Hexarelin is the strongest GHRP available, so users should notice that desensitization can come much quicker than other GHRP’s.   This makes it less ideal for long term use, but with Hexarelin’s ability to raise healthy levels of IGF-1 and GH it can work perfect as a PCT tool for those coming off a synthetic GH/IGF-1 cycle.

Hexarelin comes in a freeze dried powder just like the other GHRP peptides and storage should be done in a cool dry place until reconstituted and placed in a refrigerator.  Bacteriostatic water is used to reconstitute the powder and an insulin syringe is the preferred method for administering subcutaneous injections of Hexarelin.  Users will notice 200mcgs is the saturation dose for hexarelin and over a few weeks of use total desensitization may begin to take place.  Also, the occasional flare up of the pituitary has been noted when dosing far beyond saturation doses.  Desensitization can be cleared easily by taking a break from Hexarelin usage for a few days to a few weeks.  This GHRP is the strongest, and because of the desensitization factor,  the optimal way to use this peptide would be to blend it at low doses with other GHRP’s like GHRP2, GHRP6 or iPamorelin.  By combining a low dose of Hexarelin with another GHRP, you are going to increase your ability to put out a greater pulse of growth hormone.  Combine this with GHRH’s and you have a synergistic blend that will release GH more effectively.  In fact, for synthetic HGH users, this may be a viable way to save money on using less exogenous GH by combining it with Hexarelin in a GHRP+GHRH cycle.  As a result, utilizing Hexarelin in this protocol would establish the maximum GH release in the body.
In studies where Hexarelin was injected subcutaneously, Growth Hormone, measured through plasma concentrations, increased significantly and within thirty minutes of injection.  GH levels decreased back to normal around four hours post injection.  The GH increase, has been found to be effective up to 2mg/kg, any further increase in dose was found to be ineffective in causing a GH response.

Results showed that Hexarelin’s effect on GH stimulation tapered between weeks 4 through 16.  Separating cycles by 4 week off periods, avoided the negative feedback loop and the next cycle of Hexarelin produced the same level of results as the first cycle.
In animals, Hexarelin has been administered for longer periods. In six old beagle dogs, Cella and colleagues demonstrated a decrease in hexarelin-stimulated GH release during twice-daily sc hexarelin therapy given for periods of 7 weeks, 4 weeks, and 1 week, with no change in serum IGF-I. If the GH response to Hexarelin in humans becomes appreciably attenuated after long-term administration, then this will seriously limit the potential therapeutic use of Hexarelin and similar agents. There are no data available on the GH releasing capacity of hexarelin after long-term administration or on the effect of hexarelin-stimulated GH release on serum IGF-I and IGFBP-3 levels in normal adult subjects. Furthermore, there are few data on the GH response to Hexarelin after a period off treatment. We have, therefore, assessed the effect of 16 weeks of twice-daily sc hexarelin therapy on the GH response to a single injection of Hexarelin and also the GH response 4 weeks after cessation of Hexarelin therapy. We also have assessed the effect of Hexarelin stimulated GH release on serum IGF-I, IGFBP-3, markers of bone formation [osteocalcin, procollagen-type-III-N-terminal-peptide (PIIINP), and C-terminal propeptide of type I collagen (CICP)], and resorption (urinary deoxypyridinoline and pyridinoline), body composition, and bone mineral density (BMD).